Non-viral, Tumor-free Induction of Transient Cell Reprogramming in Mouse Skeletal Muscle to Enhance Tissue Regeneration

• Main Authors: Irene, de Lázaro, Acelya, Yilmazer, Yein, Nam, Sara, Qubisi, Maizatul Fazilah, Abd Razak, Hans, Degens, Giulio, Cossu, Kostas, Kostarelos
• Format: Article
• Language: English
• Published: The American Society of Gene and Cell Therapy 2018
• Subjects: Q Science (General); QP Physiology
• Online Access: http://ir.unimas.my/id/eprint/45806/1/1-s2.0-S1525001618305033-main.pdf; http://ir.unimas.my/id/eprint/45806/; https://www.sciencedirect.com/science/article/pii/S1525001618305033?via%3Dihub; https://doi.org/10.1016/j.ymthe.2018.10.014
• Institution: Universiti Malaysia Sarawak

Overexpression of Oct3/4, Klf4, Sox2, and c-Myc (OKSM) transcription factors can de-differentiate adult cells in vivo. While sustained OKSM expression triggers tumorigenesis through uncontrolled proliferation of toti- and pluripotent cells, transient reprogramming induces pluripotency-like features...