Pharmacological consequence of inhibiting MAPK p38 using Ralimetinib dimesylate on lipopolysaccharide-induced E-selectin and VCAM-1 expression in HUVEC

• Main Author: Dayang Erna Zulaikha, Awang Hamsin
• Format: Proceeding
• Language: English
• Published: 2022
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://ir.unimas.my/id/eprint/45861/3/Pharmacological%20consequence.pdf; http://ir.unimas.my/id/eprint/45861/
• Institution: Universiti Malaysia Sarawak

Endothelial dysfunction plays a prominent role in the pathogenesis of sepsis and is associated with life-threatening organ dysfunction. Lipopolysaccharide (LPS), a Gram-negative bacterial component, is an important sepsis associated mediator that induces the expression of adhesion molecules such as...