Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana
antimalarial agent; aporphine derivative; boldine; chloroquine; laetanine; laurolitsine; roemerine; sebiferine; tavoyanine A; unclassified drug; alkaloid; antimalarial agent; aporphine derivative; plant extract; antiplasmodial activity; Article; carbon nuclear magnetic resonance; controlled study; d...
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my.uniten.dspace-256102023-05-29T16:11:40Z Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana Omar H. Fadaeinasab M. Taha H. Widyawaruyanti A. Nafiah M.A. Rachmatiah T. 35171066800 55662460000 54279619100 21835200700 25825474900 34168294700 antimalarial agent; aporphine derivative; boldine; chloroquine; laetanine; laurolitsine; roemerine; sebiferine; tavoyanine A; unclassified drug; alkaloid; antimalarial agent; aporphine derivative; plant extract; antiplasmodial activity; Article; carbon nuclear magnetic resonance; controlled study; drug isolation; electrospray mass spectrometry; heteronuclear multiple bond correlation; heteronuclear multiple quantum coherence; in vitro study; Lauraceae; nonhuman; Phoebe tavoyana; plant leaf; Plasmodium falciparum; proton nuclear magnetic resonance; chemical structure; Alkaloids; Antimalarials; Aporphines; Lauraceae; Molecular Structure; Plant Extracts; Plant Leaves; Plasmodium falciparum One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3�6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 �g/ml, respectively. � 2019, � 2019 Informa UK Limited, trading as Taylor & Francis Group. Final 2023-05-29T08:11:40Z 2023-05-29T08:11:40Z 2020 Article 10.1080/10286020.2018.1553958 2-s2.0-85063189000 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063189000&doi=10.1080%2f10286020.2018.1553958&partnerID=40&md5=988d4537785527d2360318e9599a2f4a https://irepository.uniten.edu.my/handle/123456789/25610 22 1 52 60 Taylor and Francis Ltd. Scopus |
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antimalarial agent; aporphine derivative; boldine; chloroquine; laetanine; laurolitsine; roemerine; sebiferine; tavoyanine A; unclassified drug; alkaloid; antimalarial agent; aporphine derivative; plant extract; antiplasmodial activity; Article; carbon nuclear magnetic resonance; controlled study; drug isolation; electrospray mass spectrometry; heteronuclear multiple bond correlation; heteronuclear multiple quantum coherence; in vitro study; Lauraceae; nonhuman; Phoebe tavoyana; plant leaf; Plasmodium falciparum; proton nuclear magnetic resonance; chemical structure; Alkaloids; Antimalarials; Aporphines; Lauraceae; Molecular Structure; Plant Extracts; Plant Leaves; Plasmodium falciparum |
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35171066800 Omar H. Fadaeinasab M. Taha H. Widyawaruyanti A. Nafiah M.A. Rachmatiah T. |
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Article |
| author |
Omar H. Fadaeinasab M. Taha H. Widyawaruyanti A. Nafiah M.A. Rachmatiah T. |
| spellingShingle |
Omar H. Fadaeinasab M. Taha H. Widyawaruyanti A. Nafiah M.A. Rachmatiah T. Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
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Omar H. |
| title |
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
| title_short |
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
| title_full |
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
| title_fullStr |
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
| title_full_unstemmed |
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
| title_sort |
aporphine alkaloids with in vitro antiplasmodial activity from the leaves of phoebe tavoyana |
| publisher |
Taylor and Francis Ltd. |
| publishDate |
2023 |
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1806423998193467392 |