Development of antibacterial, degradable and ph-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing
antiinfective agent; chitosan; galactan; guar gum; mannan; plant gum; polyvinyl alcohol; administration and dosage; bacterium; bandage; chemistry; drug effect; drug release; hydrogel; wound healing; Anti-Bacterial Agents; Bacteria; Bandages; Chitosan; Drug Liberation; Galactans; Hydrogels; Mannans;...
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2023
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my.uniten.dspace-259672023-05-29T17:05:49Z Development of antibacterial, degradable and ph-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing Khan M.U.A. Iqbal I. Ansari M.N.M. Razak S.I.A. Raza M.A. Sajjad A. Jabeen F. Mohamad M.R. Jusoh N. 57195462142 57287994300 55489853600 57201381533 57190160736 55850801600 57208413161 57287280400 57192126471 antiinfective agent; chitosan; galactan; guar gum; mannan; plant gum; polyvinyl alcohol; administration and dosage; bacterium; bandage; chemistry; drug effect; drug release; hydrogel; wound healing; Anti-Bacterial Agents; Bacteria; Bandages; Chitosan; Drug Liberation; Galactans; Hydrogels; Mannans; Plant Gums; Polyvinyl Alcohol; Wound Healing The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release. Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels� crosslinking and physicochemical properties. These hydrogels were characterized using Fourier-transform infrared spec-troscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties. The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media. The FTIR analysis confirmed the components added and crosslinking between them, and surface morphology confirmed different surface and wetting behavior due to different crosslinking. In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling. In acidic pH, hydrogels swell the most, while they swell the least at pH 7 or higher. These hydrogels are pH-sensitive and appropriate for controlled drug release. These hydrogels demonstrated that, as the ionic concentration was increased, swelling decreased due to decreased osmotic pressure in various electrolyte solutions. The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains. The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min. To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker�Lonsdale, Hixson, and Peppas). It was found that hydrogel (CPG2) follows the Peppas model with the highest value of regression (R2 = 0.98509). Hence, from the results, these hydrogels could be a potential biomaterial for wound dressing in biomedical applications. � 2021 by the authors. Licensee MDPI, Basel, Switzerland. Final 2023-05-29T09:05:49Z 2023-05-29T09:05:49Z 2021 Article 10.3390/molecules26195937 2-s2.0-85116573604 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116573604&doi=10.3390%2fmolecules26195937&partnerID=40&md5=35d6a76ed18f5053ae3b8520a89a0ad7 https://irepository.uniten.edu.my/handle/123456789/25967 26 19 5937 All Open Access, Gold, Green MDPI Scopus |
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antiinfective agent; chitosan; galactan; guar gum; mannan; plant gum; polyvinyl alcohol; administration and dosage; bacterium; bandage; chemistry; drug effect; drug release; hydrogel; wound healing; Anti-Bacterial Agents; Bacteria; Bandages; Chitosan; Drug Liberation; Galactans; Hydrogels; Mannans; Plant Gums; Polyvinyl Alcohol; Wound Healing |
| author2 |
57195462142 |
| author_facet |
57195462142 Khan M.U.A. Iqbal I. Ansari M.N.M. Razak S.I.A. Raza M.A. Sajjad A. Jabeen F. Mohamad M.R. Jusoh N. |
| format |
Article |
| author |
Khan M.U.A. Iqbal I. Ansari M.N.M. Razak S.I.A. Raza M.A. Sajjad A. Jabeen F. Mohamad M.R. Jusoh N. |
| spellingShingle |
Khan M.U.A. Iqbal I. Ansari M.N.M. Razak S.I.A. Raza M.A. Sajjad A. Jabeen F. Mohamad M.R. Jusoh N. Development of antibacterial, degradable and ph-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| author_sort |
Khan M.U.A. |
| title |
Development of antibacterial, degradable and ph-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title_short |
Development of antibacterial, degradable and ph-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title_full |
Development of antibacterial, degradable and ph-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title_fullStr |
Development of antibacterial, degradable and ph-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title_full_unstemmed |
Development of antibacterial, degradable and ph-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title_sort |
development of antibacterial, degradable and ph-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| publisher |
MDPI |
| publishDate |
2023 |
| _version_ |
1806427962912800768 |