Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: Drug release, anti-microbial and cell viability studies
Chitosan; Contact angle; Controlled drug delivery; Crosslinking; Fourier transform infrared spectroscopy; Graphene oxide; Hydrogels; Medical applications; Oxide films; Phase separation; Scanning electron microscopy; Surface roughness; Targeted drug delivery; Anti-bacterial activity; Atomic-force-mic...
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my.uniten.dspace-260072023-05-29T17:06:01Z Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: Drug release, anti-microbial and cell viability studies Khan M.U.A. Yaqoob Z. Nainar M.M.A. Razak S.I.A. Raza M.A. Sajjad A. Haider S. Busra F.M. 57195462142 57266663600 57266205800 57201381533 57190160736 55850801600 35728847200 57226463504 Chitosan; Contact angle; Controlled drug delivery; Crosslinking; Fourier transform infrared spectroscopy; Graphene oxide; Hydrogels; Medical applications; Oxide films; Phase separation; Scanning electron microscopy; Surface roughness; Targeted drug delivery; Anti-bacterial activity; Atomic-force-microscopy; Cell viability; Composite hydrogels; Drug release; Hydrogels composites; PH-responsive; Poly (vinyl alcohol) (PVA); Poly(vinyl alcohol); Poly(vinyl alcohol) (PVA); Biocompatibility The composite hydrogels were produced using the solution casting method due to the non-toxic and biocompatible nature of chitosan (CS)/polyvinyl alcohol (PVA). The best composition was chosen and crosslinked with tetraethyl orthosilicate (TEOS), after which different amounts of graphene oxide (GO) were added to develop composite hydrogels. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM) and contact angle was used to analyze the hydrogels. The samples were also evaluated for swelling abilities in various mediums. The drug release profile was studied in phosphate-buffered saline (PBS) at a pH of 7.4. To predict the mechanism of drug release, the data were fitted into kinetic models. Finally, antibacterial activity and cell viability data were obtained. FTIR studies revealed the successful synthesis of CS/PVA hydrogels and GO/CS/PVA in hydrogel composite. SEM showed no phase separation of the polymers, whereas AFM showed a decrease in surface roughness with an increase in GO content. 100 �L of crosslinker was the critical concentration at which the sample displayed excellent swelling and preserved its structure. Both the crosslinked and composite hydrogel showed good swelling. The most acceptable mechanism of drug release is diffusion-controlled, and it obeys Fick�s law of diffusion for drug released. The best fitting of the zero-order, Hixson-Crowell and Higuchi models supported our assumption. The GO/CS/PVA hydrogel composite showed better antibacterial and cell viability behaviors. They can be better biomaterials in biomedical applications. � 2021 by the authors. Licensee MDPI, Basel, Switzerland. Final 2023-05-29T09:06:01Z 2023-05-29T09:06:01Z 2021 Article 10.3390/polym13183124 2-s2.0-85115330354 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115330354&doi=10.3390%2fpolym13183124&partnerID=40&md5=6cb9012a399d25649c7d755de92db9a8 https://irepository.uniten.edu.my/handle/123456789/26007 13 18 3124 All Open Access, Gold, Green MDPI Scopus |
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Chitosan; Contact angle; Controlled drug delivery; Crosslinking; Fourier transform infrared spectroscopy; Graphene oxide; Hydrogels; Medical applications; Oxide films; Phase separation; Scanning electron microscopy; Surface roughness; Targeted drug delivery; Anti-bacterial activity; Atomic-force-microscopy; Cell viability; Composite hydrogels; Drug release; Hydrogels composites; PH-responsive; Poly (vinyl alcohol) (PVA); Poly(vinyl alcohol); Poly(vinyl alcohol) (PVA); Biocompatibility |
| author2 |
57195462142 |
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57195462142 Khan M.U.A. Yaqoob Z. Nainar M.M.A. Razak S.I.A. Raza M.A. Sajjad A. Haider S. Busra F.M. |
| format |
Article |
| author |
Khan M.U.A. Yaqoob Z. Nainar M.M.A. Razak S.I.A. Raza M.A. Sajjad A. Haider S. Busra F.M. |
| spellingShingle |
Khan M.U.A. Yaqoob Z. Nainar M.M.A. Razak S.I.A. Raza M.A. Sajjad A. Haider S. Busra F.M. Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: Drug release, anti-microbial and cell viability studies |
| author_sort |
Khan M.U.A. |
| title |
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: Drug release, anti-microbial and cell viability studies |
| title_short |
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: Drug release, anti-microbial and cell viability studies |
| title_full |
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: Drug release, anti-microbial and cell viability studies |
| title_fullStr |
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: Drug release, anti-microbial and cell viability studies |
| title_full_unstemmed |
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: Drug release, anti-microbial and cell viability studies |
| title_sort |
chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies |
| publisher |
MDPI |
| publishDate |
2023 |
| _version_ |
1806423239073726464 |