Development of magnesium-doped biphasic calcium phosphatethrough sol-gel method

Calcium phosphate is an interesting material for bone implant applications, as it shows biocompatibility and bioactivity to tissue bone. Among calcium phosphate-based materials, biphasic calcium phosphate (BCP), a mixture of non-resorbable hydroxyapatite (HA) and resorbable tricalcium phosphate (TCP...

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Main Authors: Toibah A.R., Sopyan I., Hamdi M., Ramesh S.
Other Authors: 25823382300
Format: Conference paper
Published: Springer Verlag 2023
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spelling my.uniten.dspace-309962023-12-29T15:57:32Z Development of magnesium-doped biphasic calcium phosphatethrough sol-gel method Toibah A.R. Sopyan I. Hamdi M. Ramesh S. 25823382300 23482484000 17433807000 41061958200 Biphasic calcium phosphate characterization hydroxyapatite sol-gel tricalcium phosphate Additives Biocompatibility Biomedical engineering Calcium phosphate Crystallinity Fourier transform infrared spectroscopy Hydroxyapatite Magnesium metallography Metal ions Nitrates Particle size analysis Physicochemical properties Sintering Sol-gel process Sol-gels X ray diffraction Ammoniacal solution Biphasic calcium phosphates Calcium nitrate tetra-hydrate Di-ammonium hydrogen phosphate Individual particles Nucleation kinetics Osteoblastic activity Tri-calcium phosphates Magnesium compounds Calcium phosphate is an interesting material for bone implant applications, as it shows biocompatibility and bioactivity to tissue bone. Among calcium phosphate-based materials, biphasic calcium phosphate (BCP), a mixture of non-resorbable hydroxyapatite (HA) and resorbable tricalcium phosphate (TCP), has shown to possess unique characteristics appropriate for bone replacement. Doping of magnesium ions into BCP will bring biological improvement. Magnesium ion was found to cause the acceleration of nucleation kinetics of bone minerals. Magnesium depletion adversely affects all stages of skeletal metabolism, leading to decrease in osteoblastic activities and bone fragility. Therefore, the incorporation of magnesium ions into the calcium phosphate structure is of great interest for the development of artificial bone implants. Here we present magnesium-doped biphasic calcium phosphate (Mg-BCP) using chemical doping process through a solgel method. Mg-BCP was produced using calcium nitrate tetrahydrate and di-ammonium hydrogen phosphate as the precursors for calcium and phosphorus, respectively. Magnesium nitrate was used as the source of the dopant. An ammoniacal solution of the monomers was heated until a white gel was obtained. The obtained gel was then dried and subsequently subjected to calcinations. The change in physicochemical properties has been evaluated by using XRD, FTIR, TG/DTA, and FESEM. Individual particles are of less than 100 nm in size, spherical shapes and tightly agglomerated. XRD measurement shown that the powder is Mg-doped BCP with 100% purity, and crystallinity increased with increased of Mg content. FTIR spectroscopy measurement also showed that the increment of crystallinity is directly proportional to the amount of dopant leading to the conclusion that magnesium acts as a sintering additive. This result is in good agreement with the analysis of FESEM where the particles of the Mgdoped BCP are larger as the amount of dopant increased as a result of more progressive fusion of particles. � 2008 Springer-Verlag. Final 2023-12-29T07:57:32Z 2023-12-29T07:57:32Z 2008 Conference paper 10.1007/978-3-540-69139-6_80 2-s2.0-64649083106 https://www.scopus.com/inward/record.uri?eid=2-s2.0-64649083106&doi=10.1007%2f978-3-540-69139-6_80&partnerID=40&md5=1ce18f8ac83d94162f0eb041cda29eb0 https://irepository.uniten.edu.my/handle/123456789/30996 21 IFMBE 1 314 317 Springer Verlag Scopus
institution Universiti Tenaga Nasional
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content_provider Universiti Tenaga Nasional
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topic Biphasic calcium phosphate
characterization
hydroxyapatite
sol-gel
tricalcium phosphate
Additives
Biocompatibility
Biomedical engineering
Calcium phosphate
Crystallinity
Fourier transform infrared spectroscopy
Hydroxyapatite
Magnesium metallography
Metal ions
Nitrates
Particle size analysis
Physicochemical properties
Sintering
Sol-gel process
Sol-gels
X ray diffraction
Ammoniacal solution
Biphasic calcium phosphates
Calcium nitrate tetra-hydrate
Di-ammonium hydrogen phosphate
Individual particles
Nucleation kinetics
Osteoblastic activity
Tri-calcium phosphates
Magnesium compounds
spellingShingle Biphasic calcium phosphate
characterization
hydroxyapatite
sol-gel
tricalcium phosphate
Additives
Biocompatibility
Biomedical engineering
Calcium phosphate
Crystallinity
Fourier transform infrared spectroscopy
Hydroxyapatite
Magnesium metallography
Metal ions
Nitrates
Particle size analysis
Physicochemical properties
Sintering
Sol-gel process
Sol-gels
X ray diffraction
Ammoniacal solution
Biphasic calcium phosphates
Calcium nitrate tetra-hydrate
Di-ammonium hydrogen phosphate
Individual particles
Nucleation kinetics
Osteoblastic activity
Tri-calcium phosphates
Magnesium compounds
Toibah A.R.
Sopyan I.
Hamdi M.
Ramesh S.
Development of magnesium-doped biphasic calcium phosphatethrough sol-gel method
description Calcium phosphate is an interesting material for bone implant applications, as it shows biocompatibility and bioactivity to tissue bone. Among calcium phosphate-based materials, biphasic calcium phosphate (BCP), a mixture of non-resorbable hydroxyapatite (HA) and resorbable tricalcium phosphate (TCP), has shown to possess unique characteristics appropriate for bone replacement. Doping of magnesium ions into BCP will bring biological improvement. Magnesium ion was found to cause the acceleration of nucleation kinetics of bone minerals. Magnesium depletion adversely affects all stages of skeletal metabolism, leading to decrease in osteoblastic activities and bone fragility. Therefore, the incorporation of magnesium ions into the calcium phosphate structure is of great interest for the development of artificial bone implants. Here we present magnesium-doped biphasic calcium phosphate (Mg-BCP) using chemical doping process through a solgel method. Mg-BCP was produced using calcium nitrate tetrahydrate and di-ammonium hydrogen phosphate as the precursors for calcium and phosphorus, respectively. Magnesium nitrate was used as the source of the dopant. An ammoniacal solution of the monomers was heated until a white gel was obtained. The obtained gel was then dried and subsequently subjected to calcinations. The change in physicochemical properties has been evaluated by using XRD, FTIR, TG/DTA, and FESEM. Individual particles are of less than 100 nm in size, spherical shapes and tightly agglomerated. XRD measurement shown that the powder is Mg-doped BCP with 100% purity, and crystallinity increased with increased of Mg content. FTIR spectroscopy measurement also showed that the increment of crystallinity is directly proportional to the amount of dopant leading to the conclusion that magnesium acts as a sintering additive. This result is in good agreement with the analysis of FESEM where the particles of the Mgdoped BCP are larger as the amount of dopant increased as a result of more progressive fusion of particles. � 2008 Springer-Verlag.
author2 25823382300
author_facet 25823382300
Toibah A.R.
Sopyan I.
Hamdi M.
Ramesh S.
format Conference paper
author Toibah A.R.
Sopyan I.
Hamdi M.
Ramesh S.
author_sort Toibah A.R.
title Development of magnesium-doped biphasic calcium phosphatethrough sol-gel method
title_short Development of magnesium-doped biphasic calcium phosphatethrough sol-gel method
title_full Development of magnesium-doped biphasic calcium phosphatethrough sol-gel method
title_fullStr Development of magnesium-doped biphasic calcium phosphatethrough sol-gel method
title_full_unstemmed Development of magnesium-doped biphasic calcium phosphatethrough sol-gel method
title_sort development of magnesium-doped biphasic calcium phosphatethrough sol-gel method
publisher Springer Verlag
publishDate 2023
_version_ 1806426085194203136