The edema inducing activity of phospholipase A2 enzymes
The edema inducing activity of phospholipase A2 (PLA2) enzymes from snake venoms and porcine pancreas was investigated using mouse paw as experimental model. All ten PLA2 enzymes exhibited potent edema inducing activity. PLA2, however, is generally not the major edema inducing component of snake ven...
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my.uniten.dspace-60502018-02-21T03:49:23Z The edema inducing activity of phospholipase A2 enzymes Tan, N.-H. Saifuddin, M.N. Young, W.-Y. The edema inducing activity of phospholipase A2 (PLA2) enzymes from snake venoms and porcine pancreas was investigated using mouse paw as experimental model. All ten PLA2 enzymes exhibited potent edema inducing activity. PLA2, however, is generally not the major edema inducing component of snake venom. Chemical modification studies indicated that enzymatic activity of PLA2 was required for its edema inducing activity. All PLA2 enzymes examined displayed a rapid onset edema which was suppressed by pretreatment of the mice with antihistamine. Dexamethasone pretreatment also inhihited edemas elicited by some PLA2 enzymes. 2017-12-08T08:12:26Z 2017-12-08T08:12:26Z 1991 Article https://pure.uniten.edu.my/en/publications/the-edema-inducing-activity-of-phospholipase-asub2sub-enzymes en_US The edema inducing activity of phospholipase A2 enzymes. Biochemistry International, 23(1), 175-181 |
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The edema inducing activity of phospholipase A2 (PLA2) enzymes from snake venoms and porcine pancreas was investigated using mouse paw as experimental model. All ten PLA2 enzymes exhibited potent edema inducing activity. PLA2, however, is generally not the major edema inducing component of snake venom. Chemical modification studies indicated that enzymatic activity of PLA2 was required for its edema inducing activity. All PLA2 enzymes examined displayed a rapid onset edema which was suppressed by pretreatment of the mice with antihistamine. Dexamethasone pretreatment also inhihited edemas elicited by some PLA2 enzymes. |
| format |
Article |
| author |
Tan, N.-H. Saifuddin, M.N. Young, W.-Y. |
| spellingShingle |
Tan, N.-H. Saifuddin, M.N. Young, W.-Y. The edema inducing activity of phospholipase A2 enzymes |
| author_facet |
Tan, N.-H. Saifuddin, M.N. Young, W.-Y. |
| author_sort |
Tan, N.-H. |
| title |
The edema inducing activity of phospholipase A2 enzymes |
| title_short |
The edema inducing activity of phospholipase A2 enzymes |
| title_full |
The edema inducing activity of phospholipase A2 enzymes |
| title_fullStr |
The edema inducing activity of phospholipase A2 enzymes |
| title_full_unstemmed |
The edema inducing activity of phospholipase A2 enzymes |
| title_sort |
edema inducing activity of phospholipase a2 enzymes |
| publishDate |
2017 |
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1644493829423759360 |