Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases
Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that affect the nervous system and heart, all of which are vital to the human body. To maintain health of the human body, vegetable diets serve as a preventive approach and particularly Brassica vegetables have been a...
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my.upm.eprints.1005242023-11-21T08:39:19Z http://psasir.upm.edu.my/id/eprint/100524/ Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases Muhammad Kamal, Ramla Abdull Razis, Ahmad Faizal Mohd Sukri, Nurul Syafuhah Perimal, Enoch Kumar Ahmad, Hafandi Patrick, Rollin Djedaini-Pilard, Florence Mazzon, Emanuela Rigaud, Sébastien Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that affect the nervous system and heart, all of which are vital to the human body. To maintain health of the human body, vegetable diets serve as a preventive approach and particularly Brassica vegetables have been associated with lower risks of chronic diseases, especially NDDs and CVDs. Interestingly, glucosinolates (GLs) and isothiocyanates (ITCs) are phytochemicals that are mostly found in the Cruciferae family and they have been largely documented as antioxidants contributing to both cardio- and neuroprotective effects. The hydrolytic breakdown of GLs into ITCs such as sulforaphane (SFN), phenylethyl ITC (PEITC), moringin (MG), erucin (ER), and allyl ITC (AITC) has been recognized to exert significant effects with regards to cardio- and neuroprotection. From past in vivo and/or in vitro studies, those phytochemicals have displayed the ability to mitigate the adverse effects of reactive oxidation species (ROS), inflammation, and apoptosis, which are the primary causes of CVDs and NDDs. This review focuses on the protective effects of those GL-derived ITCs, featuring their beneficial effects and the mechanisms behind those effects in CVDs and NDDs MDPI 2022-01-19 Article PeerReviewed Muhammad Kamal, Ramla and Abdull Razis, Ahmad Faizal and Mohd Sukri, Nurul Syafuhah and Perimal, Enoch Kumar and Ahmad, Hafandi and Patrick, Rollin and Djedaini-Pilard, Florence and Mazzon, Emanuela and Rigaud, Sébastien (2022) Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases. Molecules, 27 (3). art. no. 624. pp. 1-49. ISSN 1420-3049 https://www.mdpi.com/1420-3049/27/3/624 10.3390/molecules27030624 |
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Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that affect the nervous system and heart, all of which are vital to the human body. To maintain health of the human body, vegetable diets serve as a preventive approach and particularly Brassica vegetables have been associated with lower risks of chronic diseases, especially NDDs and CVDs. Interestingly, glucosinolates (GLs) and isothiocyanates (ITCs) are phytochemicals that are mostly found in the Cruciferae family and they have been largely documented as antioxidants contributing to both cardio- and neuroprotective effects. The hydrolytic breakdown of GLs into ITCs such as sulforaphane (SFN), phenylethyl ITC (PEITC), moringin (MG), erucin (ER), and allyl ITC (AITC) has been recognized to exert significant effects with regards to cardio- and neuroprotection. From past in vivo and/or in vitro studies, those phytochemicals have displayed the ability to mitigate the adverse effects of reactive oxidation species (ROS), inflammation, and apoptosis, which are the primary causes of CVDs and NDDs. This review focuses on the protective effects of those GL-derived ITCs, featuring their beneficial effects and the mechanisms behind those effects in CVDs and NDDs |
format |
Article |
author |
Muhammad Kamal, Ramla Abdull Razis, Ahmad Faizal Mohd Sukri, Nurul Syafuhah Perimal, Enoch Kumar Ahmad, Hafandi Patrick, Rollin Djedaini-Pilard, Florence Mazzon, Emanuela Rigaud, Sébastien |
spellingShingle |
Muhammad Kamal, Ramla Abdull Razis, Ahmad Faizal Mohd Sukri, Nurul Syafuhah Perimal, Enoch Kumar Ahmad, Hafandi Patrick, Rollin Djedaini-Pilard, Florence Mazzon, Emanuela Rigaud, Sébastien Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases |
author_facet |
Muhammad Kamal, Ramla Abdull Razis, Ahmad Faizal Mohd Sukri, Nurul Syafuhah Perimal, Enoch Kumar Ahmad, Hafandi Patrick, Rollin Djedaini-Pilard, Florence Mazzon, Emanuela Rigaud, Sébastien |
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Muhammad Kamal, Ramla |
title |
Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases |
title_short |
Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases |
title_full |
Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases |
title_fullStr |
Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases |
title_full_unstemmed |
Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases |
title_sort |
beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases |
publisher |
MDPI |
publishDate |
2022 |
url |
http://psasir.upm.edu.my/id/eprint/100524/ https://www.mdpi.com/1420-3049/27/3/624 |
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1783879923712131072 |