Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry

Vitamin D deficiency during pregnancy has been associated with poor foetal growth and neonatal birth anthropometry. However, the associations were inconsistent and could be confounded by neonatal vitamin D status and genetic factors. Until recently, limited studies have concomitantly examined the ef...

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Main Authors: Lee, Siew Siew, Ling, King Hwa, Tusimin, Maiza, Subramaniam, Raman, Rahim, Kartini Farah, Loh, Su Peng
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2022
Online Access:http://psasir.upm.edu.my/id/eprint/101966/
https://www.mdpi.com/2072-6643/14/3/564
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spelling my.upm.eprints.1019662023-06-16T20:15:10Z http://psasir.upm.edu.my/id/eprint/101966/ Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry Lee, Siew Siew Ling, King Hwa Tusimin, Maiza Subramaniam, Raman Rahim, Kartini Farah Loh, Su Peng Vitamin D deficiency during pregnancy has been associated with poor foetal growth and neonatal birth anthropometry. However, the associations were inconsistent and could be confounded by neonatal vitamin D status and genetic factors. Until recently, limited studies have concomitantly examined the effect of maternal and neonatal vitamin D deficiency and vitamin D-related single nucleotide polymorphisms (SNPs) on neonatal birth anthropometry. This study aims to examine the independent and combined effects of maternal and neonatal vitamin D deficiency and vitamin-D-related SNPs on neonatal birth anthropometry. This cross-sectional study included 217 mother–neonate dyads recruited from Hospital Serdang, Selangor, Malaysia, between 2015 and 2017. Plasma 25-hydroxyvitamin D (25OHD) concentration was measured in maternal and umbilical cord blood using ultra-high-performance liquid chromatography (UHPLC). Maternal and neonatal vitamin D Receptor (VDR) SNP (rs2228570) genotypes were determined using high-resolution melting (HRM). Group-specific component (GC) SNPs (rs4588 and rs7041) genotypes were determined using restriction fragment length polymorphism. Our results showed that: (1) maternal vitamin D deficiency (25OHD < 30 nmol/L) was inversely associated with birth weight, head circumference and crown–heel length; (2) neonatal SNPs, VDR rs2228570 and GC rs4588, were significantly associated with birth weight and head circumference, respectively; and (3) a potential interaction was observed between maternal VDR rs2228570 with maternal vitamin D deficiency on head circumference. These findings suggest that the underlying mechanisms of vitamin D on foetal growth are likely to be localised in the maternal compartment, mediated through the placenta, rather than through cellular mechanisms within the foetus. Further large-scale studies are warranted to validate and extend these findings. Multidisciplinary Digital Publishing Institute 2022-01-27 Article PeerReviewed Lee, Siew Siew and Ling, King Hwa and Tusimin, Maiza and Subramaniam, Raman and Rahim, Kartini Farah and Loh, Su Peng (2022) Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry. Nutrients, 14 (3). art. no. 564. pp. 1-13. ISSN 2072-6643 https://www.mdpi.com/2072-6643/14/3/564 10.3390/nu14030564
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
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url_provider http://psasir.upm.edu.my/
description Vitamin D deficiency during pregnancy has been associated with poor foetal growth and neonatal birth anthropometry. However, the associations were inconsistent and could be confounded by neonatal vitamin D status and genetic factors. Until recently, limited studies have concomitantly examined the effect of maternal and neonatal vitamin D deficiency and vitamin D-related single nucleotide polymorphisms (SNPs) on neonatal birth anthropometry. This study aims to examine the independent and combined effects of maternal and neonatal vitamin D deficiency and vitamin-D-related SNPs on neonatal birth anthropometry. This cross-sectional study included 217 mother–neonate dyads recruited from Hospital Serdang, Selangor, Malaysia, between 2015 and 2017. Plasma 25-hydroxyvitamin D (25OHD) concentration was measured in maternal and umbilical cord blood using ultra-high-performance liquid chromatography (UHPLC). Maternal and neonatal vitamin D Receptor (VDR) SNP (rs2228570) genotypes were determined using high-resolution melting (HRM). Group-specific component (GC) SNPs (rs4588 and rs7041) genotypes were determined using restriction fragment length polymorphism. Our results showed that: (1) maternal vitamin D deficiency (25OHD < 30 nmol/L) was inversely associated with birth weight, head circumference and crown–heel length; (2) neonatal SNPs, VDR rs2228570 and GC rs4588, were significantly associated with birth weight and head circumference, respectively; and (3) a potential interaction was observed between maternal VDR rs2228570 with maternal vitamin D deficiency on head circumference. These findings suggest that the underlying mechanisms of vitamin D on foetal growth are likely to be localised in the maternal compartment, mediated through the placenta, rather than through cellular mechanisms within the foetus. Further large-scale studies are warranted to validate and extend these findings.
format Article
author Lee, Siew Siew
Ling, King Hwa
Tusimin, Maiza
Subramaniam, Raman
Rahim, Kartini Farah
Loh, Su Peng
spellingShingle Lee, Siew Siew
Ling, King Hwa
Tusimin, Maiza
Subramaniam, Raman
Rahim, Kartini Farah
Loh, Su Peng
Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry
author_facet Lee, Siew Siew
Ling, King Hwa
Tusimin, Maiza
Subramaniam, Raman
Rahim, Kartini Farah
Loh, Su Peng
author_sort Lee, Siew Siew
title Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry
title_short Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry
title_full Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry
title_fullStr Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry
title_full_unstemmed Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry
title_sort interplay between maternal and neonatal vitamin d deficiency and vitamin-d-related gene polymorphism with neonatal birth anthropometry
publisher Multidisciplinary Digital Publishing Institute
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/101966/
https://www.mdpi.com/2072-6643/14/3/564
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