The effect of Aflatoxin B1 on tumor-related genes and phenotypic characters of MCF7 and MCF10A cells

• Main Authors: Ahmed Adam, Mowaffaq Adam, Muhd Kamal, Laina Zarisa, Kanakal, Mahibub, Babu, Dinesh, Dahham, Saad Sabbar, Tabana, Yasser, Lok, Bronwyn, Bermoy, Brittany M., Yunus, Muhammad Amir, Than, Leslie Thian Lung, Barakat, Khaled, Sandai, Doblin
• Format: Article
• Published: Multidisciplinary Digital Publishing Institute 2022
• Online Access: http://psasir.upm.edu.my/id/eprint/103499/; https://www.mdpi.com/1422-0067/23/19/11856
• Institution: Universiti Putra Malaysia

The fungal toxin aflatoxin B1 (AB1) and its reactive intermediate, aflatoxin B1-8, 9 epoxide, could cause liver cancer by inducing DNA adducts. AB1 exposure can induce changes in the expression of several cancer-related genes. In this study, the effect of AB1 exposure on breast cancer MCF7 and norma...