Non-lamellar lyotropic liquid crystalline nanoparticles as nanocarriers for enhanced drug encapsulation of atorvastatin calcium and proanthocyanidins

• Main Authors: Maslizan, Mardhiah, Haris, Muhammad Salahuddin, Ajat, Mokrish, Md Jamil, Siti Nurul Ain, Azhar, Shah Christirani, Zahid, N. Idayu, Mat Azmi, Intan Diana
• Format: Article
• Published: Elsevier BV 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/106327/; https://linkinghub.elsevier.com/retrieve/pii/S0009308424000021
• Institution: Universiti Putra Malaysia

Atorvastatin calcium (ATV) and proanthocyanidins (PAC) have a strong antioxidant activity, that can benefit to reduce the atherosclerotic plaque progression. Unfortunately, the bioavailability of ATV is greatly reduced due to its limited drug solubility while the PAC drug is unstable upon exposure t...