Clinical features and mutational analysis of X-linked agammaglobulinemia patients in Malaysia

• Main Authors: Chear, Chai Teng, Ismail, Intan Hakimah, Chan, Kwai Cheng, Mohd Noh, Lokman, Kassim, Asiah, Abdul Latiff, Amir Hamzah, Gill, Sandeep Singh, Ramly, Nazatul Haslina, Tan, Kah Kee, Sundaraj, Charlotte, Choo, Chong Ming, Syed Mohamed, Sharifah Adlena, Baharin, Mohd Farid, Zamri, Amelia Suhana, Syed Yahya, Sharifah Nurul Husna, Mohamad, Saharuddin, Mat Ripen, Adiratna
• Format: Article
• Language: English
• Published: Frontiers Media 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/107037/1/Clinical%20features%20and%20mutational%20analysis%20of%20X-linked%20agammaglobulinemia%20patients%20in%20Malaysia.pdf; http://psasir.upm.edu.my/id/eprint/107037/; https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1252765/full
• Institution: Universiti Putra Malaysia

Bruton’s tyrosine kinase (BTK) is a cytoplasmic protein involved in the B cell development. X-linked agammaglobulinemia (XLA) is caused by mutation in the BTK gene, which results in very low or absent B cells. Affected males have markedly reduced immunoglobulin levels, which render them susceptible...