Discovery of ruthenium(ii) metallocompound and olaparib synergy for cancer combination therapy

• Main Authors: Yusoh, Nur Aininie, Tiley, Paul R., James, Steffan D., Harun, Siti Norain, Thomas, Jim A., Saad, Norazalina, Ling, Wei Hii, Suet, Lin Chia, Gill, Martin R., Ahmad, Haslina
• Format: Article
• Language: English
• Published: American Chemical Society 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/107358/1/107358.pdf; http://psasir.upm.edu.my/id/eprint/107358/; https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00322
• Institution: Universiti Putra Malaysia

Synergistic drug combinations can extend the use of poly(ADP-ribose) polymerase inhibitors (PARPi) such as Olaparib to BRCA-proficient tumors and overcome acquired or de novo drug resistance. To identify new synergistic combinations for PARPi, we screened a “micro-library” comprising a mix of commer...