Drug repurposing of clinically approved drugs to target epithelial-mesenchymal transition using molecular docking approach

• Main Authors: Chun Hao, Ong, Chau Ling, Tham, Harith, Hanis Hazeera, Firdaus, Nazmi, Ahmad Israf, Daud
• Format: Article
• Language: English
• Published: Universiti Putra Malaysia Press 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/107414/1/107414.pdf; http://psasir.upm.edu.my/id/eprint/107414/; https://medic.upm.edu.my/upload/dokumen/2023091810365503_MJMHS_1210.pdf
• Institution: Universiti Putra Malaysia

Introduction: Epithelial-mesenchymal transition (EMT) is a process of epithelial transformation into mesenchymal cells. It is also a process that contributes to the progression of fibrosis and cancer metastasis. Transforming growth factor-beta (TGF-²), as a potent inducer of EMT, has therefore becam...