Hyaluronic acid/chitosan-coated poly (lactic-co-glycolic acid) nanoparticles to deliver single and co-loaded paclitaxel and temozolomide for CD44+oral cancer cells

• Main Authors: Mesrati, Malak Hassn, Ahmad Tajudin, Asilah, Masarudin, Mas Jaffri, Alamassi, Mohammed Numan, Abuhamad, Asma Y., Syahir, Amir
• Format: Article
• Published: Elsevier BV 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/108218/; https://linkinghub.elsevier.com/retrieve/pii/S2352952023000452
• Institution: Universiti Putra Malaysia

Oral cancer has a poor survival rate despite comprehensive therapy. Current treatments result in acute side effects and fail to eliminate an aggressive group of cells overexpressing CD44. Such cells are capable of tumour initiating, self-renewal, invasion and metastasis, resulting in tumour relapse...