Increased efficacy of biologics following inhibition of autophagy in A549 lung cancer cells in bimodal treatment of doxorubicin and SAR405-loaded chitosan nanoparticles

• Main Authors: Alamassi, Mohammed Numan, Chia, Suet Lin, Che Abdullah, Che Azurahanim, Masarudin, Mas Jaffri
• Format: Article
• Published: Elsevier 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/109118/; https://linkinghub.elsevier.com/retrieve/pii/S235295202300021X
• Institution: Universiti Putra Malaysia

Conventional anti-cancer drugs, including doxorubicin, are associated with high toxicity and non-specific distribution in the body which results in a cascade of side effects. Cancer cells can utilize autophagy to promote tolerance to the stress induced by anti-cancer agents; this may be the major ca...