Synergy of ruthenium metallo-intercalator, [Ru(dppz)2(PIP)]2+, with PARP inhibitor Olaparib in non-small cell lung cancer cells

• Main Authors: Yusoh, Nur Aininie, Chia, Suet Lin, Saad, Norazalina, Ahmad, Haslina, Gill, Martin R.
• Format: Article
• Published: Nature Publishing 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/109311/; https://www.nature.com/articles/s41598-023-28454-x?error=cookies_not_supported&code=76e60f36-2a34-427f-8afe-0a710119131a
• Institution: Universiti Putra Malaysia

Poly(ADP-ribose) polymerase (PARP) are critical DNA repair enzymes that are activated as part of the DNA damage response (DDR). Although inhibitors of PARP (PARPi) have emerged as small molecule drugs and have shown promising therapeutic effects, PARPi used as single agents are clinically limited to...