In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract

• Main Authors: Zulkifli, Siti Atikah, Abd Gani, Siti Salwa, Zaidan, Uswatun Hasanah, Misran, Azizah, Hassan, Masriana
• Format: Article
• Language: English
• Published: Taylor and Francis Ltd. 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/111540/1/In%20vitro%20anti-inflammatory%20and%20wound%20healing%20properties%20of%20defatted%20Selenicereus%20monacanthus%20%20Lem.%20%20D.R.Hunt%20seed%20extract%20%281%29.pdf; http://psasir.upm.edu.my/id/eprint/111540/; https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2344190
• Institution: Universiti Putra Malaysia

Extracts from Selenicereus monacanthus (synonym: Hylocereus polyrhizus) have received attention due to their potent anti-inflammatory, antioxidant, anticancer, and antidiabetic properties. The current study aims to determine the anti-inflammatory and wound-healing potential of defatted S. monacanthus seed extract (DSMSE). Anti-inflammatory properties of DSMSE on LPS-induced inflammation on THP-1 were determined by measuring the levels of interleukins IL-6, IL-8, and IL-10. Wound healing scratch assay was performed using the human fibroblast (Hs27) cell that assesses the cell migration over 24 h exposure to DSMSE. Administration of DSMSE significantly reduced the LPS-stimulated release levels of IL-6 and IL-8 and significantly increased the levels of IL-10. Treatment with DSMSE showed a significant increase in wound closure with 70% of fibroblast migration. Therefore, the current study showed the anti-inflammatory and wound healing properties of DSMSE reducing inflammatory cytokines (IL-6 and IL-8), increasing IL-10 cytokine, and increasing wound closure at 24 h.