Revealing metabolic and biochemical variations via 1H NMR metabolomics in streptozotocin-nicotinamide-induced diabetic rats treated with metformin

• Main Authors: Zolkeflee, Nur Khaleeda Zulaikha, Wong, Pei Lou, Maulidiani, M., Ramli, Nurul Shazini, Azlan, Azrina, Mediani, Ahmed, Tham, Chau Ling, Abas, Faridah
• Format: Article
• Published: Elsevier 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/112061/; https://www.sciencedirect.com/science/article/abs/pii/S0006291X24003140?via%3Dihub
• Institution: Universiti Putra Malaysia

The increasing prevalence of lean diabetes has prompted the generation of animal models that mimic metabolic disease in humans. This study aimed to determine the optimum streptozotocin-nicotinamide (STZ-NA) dosage ratio to elicit lean diabetic features in a rat model. It also used a proton nuclear m...