Catalytically active inclusion bodies as a potential tool for biotechnology

The initial assumption that viewed inclusion bodies as a hindrance to the efficient production of protein is no longer held due to the emergence of catalytically active inclusion bodies (CatIBs). Recent studies revealed their potential to be used in free form or immobilized as biocatalysts. The curi...

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Main Authors: Bello, Muhammad Nura, Sabri, Suriana, Mohd Yahaya, Normi, Mohd Shariff, Fairolniza, Mohamad Ali, Mohd Shukuri
Format: Article
Language:English
Published: John Wiley and Sons 2024
Online Access:http://psasir.upm.edu.my/id/eprint/115416/1/115416.pdf
http://psasir.upm.edu.my/id/eprint/115416/
https://iubmb.onlinelibrary.wiley.com/doi/10.1002/bab.2624
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Institution: Universiti Putra Malaysia
Language: English
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spelling my.upm.eprints.1154162025-03-04T03:44:58Z http://psasir.upm.edu.my/id/eprint/115416/ Catalytically active inclusion bodies as a potential tool for biotechnology Bello, Muhammad Nura Sabri, Suriana Mohd Yahaya, Normi Mohd Shariff, Fairolniza Mohamad Ali, Mohd Shukuri The initial assumption that viewed inclusion bodies as a hindrance to the efficient production of protein is no longer held due to the emergence of catalytically active inclusion bodies (CatIBs). Recent studies revealed their potential to be used in free form or immobilized as biocatalysts. The curiosity to acquire suitable catalysts has remained the measure of concern for researchers and industrialists. Numerous processes and production in various sectors of food industries, petroleum, pharmaceutical, cosmetics, and many others are still searching for a robust catalyst with outstanding features such as recyclability, resistance to pH, as well as temperature. CatIBs are forms of inclusion bodies that possess catalytic activity, which can improve catalysis efficiency, stability, and recyclability. One of the advantages of CatIBs is their potential to be used as catalysts for numerous bioprocesses when generated by an enzyme. These aggregates can efficiently be used as a replacement for traditional enzyme immobilization. This review tends to focus on the possibility of its application in various processes. The novelty of this review is that it considered the production of CatIBs both from artificial and natural perspectives, as well as how to improve it. Inclusion bodies’ immobilization may provide an efficient alternative in the area of biocatalysis, and hence it will improve industrial sectors and substantially provide a means of achieving excellent performance in the near future. John Wiley and Sons 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/115416/1/115416.pdf Bello, Muhammad Nura and Sabri, Suriana and Mohd Yahaya, Normi and Mohd Shariff, Fairolniza and Mohamad Ali, Mohd Shukuri (2024) Catalytically active inclusion bodies as a potential tool for biotechnology. Biotechnology and Applied Biochemistry, 71 (6). pp. 1235-1242. ISSN 0885-4513; eISSN: 1470-8744 https://iubmb.onlinelibrary.wiley.com/doi/10.1002/bab.2624 10.1002/bab.2624
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The initial assumption that viewed inclusion bodies as a hindrance to the efficient production of protein is no longer held due to the emergence of catalytically active inclusion bodies (CatIBs). Recent studies revealed their potential to be used in free form or immobilized as biocatalysts. The curiosity to acquire suitable catalysts has remained the measure of concern for researchers and industrialists. Numerous processes and production in various sectors of food industries, petroleum, pharmaceutical, cosmetics, and many others are still searching for a robust catalyst with outstanding features such as recyclability, resistance to pH, as well as temperature. CatIBs are forms of inclusion bodies that possess catalytic activity, which can improve catalysis efficiency, stability, and recyclability. One of the advantages of CatIBs is their potential to be used as catalysts for numerous bioprocesses when generated by an enzyme. These aggregates can efficiently be used as a replacement for traditional enzyme immobilization. This review tends to focus on the possibility of its application in various processes. The novelty of this review is that it considered the production of CatIBs both from artificial and natural perspectives, as well as how to improve it. Inclusion bodies’ immobilization may provide an efficient alternative in the area of biocatalysis, and hence it will improve industrial sectors and substantially provide a means of achieving excellent performance in the near future.
format Article
author Bello, Muhammad Nura
Sabri, Suriana
Mohd Yahaya, Normi
Mohd Shariff, Fairolniza
Mohamad Ali, Mohd Shukuri
spellingShingle Bello, Muhammad Nura
Sabri, Suriana
Mohd Yahaya, Normi
Mohd Shariff, Fairolniza
Mohamad Ali, Mohd Shukuri
Catalytically active inclusion bodies as a potential tool for biotechnology
author_facet Bello, Muhammad Nura
Sabri, Suriana
Mohd Yahaya, Normi
Mohd Shariff, Fairolniza
Mohamad Ali, Mohd Shukuri
author_sort Bello, Muhammad Nura
title Catalytically active inclusion bodies as a potential tool for biotechnology
title_short Catalytically active inclusion bodies as a potential tool for biotechnology
title_full Catalytically active inclusion bodies as a potential tool for biotechnology
title_fullStr Catalytically active inclusion bodies as a potential tool for biotechnology
title_full_unstemmed Catalytically active inclusion bodies as a potential tool for biotechnology
title_sort catalytically active inclusion bodies as a potential tool for biotechnology
publisher John Wiley and Sons
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/115416/1/115416.pdf
http://psasir.upm.edu.my/id/eprint/115416/
https://iubmb.onlinelibrary.wiley.com/doi/10.1002/bab.2624
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