Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice

• Main Authors: Tengku Mohamad, Tengku Azam Shah, Akhtar, Mohamad Nadeem, Zakaria, Zainul Amiruddin, Perimal, Enoch Kumar, Khalid, Syamimi, P. A. Mohd, Khalid, Mohamed Hanief, Israf Ali, Daud Ahmad, Lajis, Md. Nordin, Sulaiman, Mohd Roslan
• Format: Article
• Language: English
• Published: Elsevier 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/13161/1/Antinociceptive%20activity%20of%20a%20synthetic%20chalcone.pdf; http://psasir.upm.edu.my/id/eprint/13161/
• Institution: Universiti Putra Malaysia

The present study examined the potential antinociceptive activity of flavokawin B (6'-hydroxy-2',4'-dimethoxychalcone), a synthetic chalcone using chemical- and thermal-induced nociception models in mice. It was demonstrated that flavokawin B (FKB; 0.3, 1, 3 and 10 mg/kg) administered...