Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models

• Main Authors: Zakaria, Zainul Amiruddin, Sulaiman, Mohd Roslan, Morsid, Nur Atiqah, Aris, Anwariah, Zainal, Hairani, Mohd Pojan, Nur Hidayu, Kumar, Gopalan Hanan
• Format: Article
• Language: English
• Published: Prous Science 2009
• Online Access: http://psasir.upm.edu.my/id/eprint/13173/1/Antinociceptive%2C%20anti-inflammatory%20and%20antipyretic%20effects%20of%20solanum%20nigrum%20aqueous%20extract%20in%20animal%20models.pdf; http://psasir.upm.edu.my/id/eprint/13173/
• Institution: Universiti Putra Malaysia

The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of the aqueous extract of Solanum nigrum leaves using various animal models. The extract, at concentrations of 10, 50 and 100%, was prepared by soaking (1:20; w/v) air-dried powdered leaves (20 g) in distilled water (dH2O) for 72 h. The extract solutions were administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (P < 0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Overall, these activities occurred in a concentration-dependent manner, except for the 50% concentration of the extract, which was not effective in the abdominal constriction test. In conclusion, the present study demonstrated that S. nigrum leaves possessed antinociceptive, anti-inflammatory and antipyretic effects and thus supported traditional claims of its medicinal uses.