Atrovirinone inhibits proinflammatory mediator synthesis through disruption of NF-kappaB nuclear translocation and MAPK phosphorylation in the murine monocytic macrophage RAW 264.7.

• Main Authors: Israf Ali, Daud Ahmad, Tham, Chau Ling, Ahmad, Syahida, Lajis, Md. Nordin, Sulaiman, Mohd Roslan, Mohamad, Azam Shah, Zakaria, Zainul Amiruddin
• Format: Article
• Language: English; English
• Published: Elsevier 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/13323/1/Atrovirinone%20inhibits%20proinflammatory%20mediator%20synthesis%20through%20disruption%20of%20NF.pdf; http://psasir.upm.edu.my/id/eprint/13323/; http://www.phytomedicinejournal.com/
• Institution: Universiti Putra Malaysia

In a previous communication we showed that atrovirinone, a 1,4-benzoquinone isolated from the roots of Garcinia atroviridis, was able to inhibit several major proinflammatory mediators of inflammation. In this report we show that atrovirinone inhibits NO and PGE2 synthesis through inhibition of iNOS...