Cis-clerodane-type furanoditerpenoids from Tinospora crispa

• Main Authors: Choudhary, Muhammad Iqbal, Muhammad Ismail, Shaari, Khozirah, Ahmed Abbaskhan, A. Sattar, Samina, Lajis, Md. Nordin, Atta-ur-Rahman
• Format: Article
• Language: English
• Published: American Chemical Society 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/13597/1/Cis-clerodane-type%20furanoditerpenoids%20from%20Tinospora%20crispa.pdf; http://psasir.upm.edu.my/id/eprint/13597/; http://pubs.acs.org/doi/abs/10.1021/np900551u
• Institution: Universiti Putra Malaysia

Phytochemical and cytotoxicity investigations on organic solvent extracts of the aerial parts of Tinospora crispa have led to the isolation of 15 cis-clerodane-type furanoditerpenoids. Of these, nine compounds (1-9) were found to be new. Spectroscopic assignments of a previously reported compound, borapetoside A (13), were revised on the basis of HMQC and HMBC correlations. No discernible activity was observed when compounds 10-13 were subjected to evaluation in cytotoxicity assays against human prostate cancer (PC-3) and the normal mouse fibroblast (3T3) cell lines.