Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest

• Main Authors: Sarmadi, Vahid Hosseinpour, Tong, Chih Kong, Vidyadaran, Sharmili, Abdullah, Maha, Seow, Heng Fong, Ramasamy, Rajesh
• Format: Article
• Language: English
• Published: Malaysian Medical Association 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/15613/1/Mesenchymal%20stem%20cells%20inhibit%20proliferation%20of%20lymphoid%20origin%20haematopoietic%20tumour%20cells%20by%20inducing%20cell%20cycle%20arrest.pdf; http://psasir.upm.edu.my/id/eprint/15613/; http://www.e-mjm.org/2010/v65n3/index.html
• Institution: Universiti Putra Malaysia

We have previously shown that mesenchymal stem cells (MSC) inhibit tumour cell proliferation, thus promising a novel therapy for treating cancers. In this study, MSC were generated from human bone marrow samples and characterised based on standard immunophenotyping. When MSC were co-cultured with BV173 and Jurkat tumour cells, the proliferation of tumour cells were profoundly inhibited in a dose dependent manner mainly via cell to cell contact interaction. Further cell cycle analysis reveals that MSC arrest tumour cell proliferation in G0/G1 phase of cell cycle thus preventing the entry of tumour cells into S phase of cell cycle.