Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model

• Main Authors: Bala, Usman, Leong, Melody Pui Yee, Lim, Chai Ling, Kadir @ Shahar, Hayati, Othman, Fauziah, Lai, Mei I., Law, Zhe Kang, Ramli, Khairunnisa, Htwe, Ohnmar, Ling, King Hwa, Cheah, Pike See
• Format: Article
• Language: English
• Published: Public Library of Science 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/15954/1/15954.pdf; http://psasir.upm.edu.my/id/eprint/15954/; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197711
• Institution: Universiti Putra Malaysia

Background: Down syndrome (DS) is a genetic disorder caused by presence of extra copy of human chromosome 21. It is characterised by several clinical phenotypes. Motor dysfunction due to hypotonia is commonly seen in individuals with DS and its etiology is yet unknown. Ts1Cje, which has a partial tr...