Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99
A 13 year old boy presented with a huge mass on his right arm of 6 months duration. Histopathological examination revealed sheets of malignant small round blue cells with immunopositivity for LCA, CD43, CD45Ro, CD30, EMA, ALK-1 and CD99, and negativity for CD20, TdT, myogenin, myoD1, NSE, bcl-6, bcl...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Malaysian Medical Association
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/16740/1/Small%20cell%20variant%20of%20anaplastic%20large%20cell%20lymphoma%20with%20positive%20immunoreactivity%20for%20CD99.pdf http://psasir.upm.edu.my/id/eprint/16740/ http://www.e-mjm.org/2008/v63n2/index.html |
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| Institution: | Universiti Putra Malaysia |
| Language: | English |
| Summary: | A 13 year old boy presented with a huge mass on his right arm of 6 months duration. Histopathological examination revealed sheets of malignant small round blue cells with immunopositivity for LCA, CD43, CD45Ro, CD30, EMA, ALK-1 and CD99, and negativity for CD20, TdT, myogenin, myoD1, NSE, bcl-6, bcl-2 and CD10. Fluorescent In-Situ Hybridization (FISH) testing excluded the diagnosis of Ewing's sarcoma/ PNET. Pathologists need to be aware of the diagnosis of a small cell variant of ALCL, as well as of the fact that CD99 expression commonly occurs in cases of ALK-positive ALCL, in order to distinguish this entity from Ewing's sarcoma/PNET. |
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