Oral vaccine of Lactococcus lactis harbouring pandemic H1N1 2009 haemagglutinin1 and nisP anchor fusion protein elevates anti-HA1 sIgA levels in mice

• Main Authors: Siaw, Stella Xiu Joan, Jee, Pui Fong, Song, Adelene Ai Lian, Chang, Li Yen, Yusoff, Khatijah, Abu Bakar, Sazaly, Abdul Rahim, Raha
• Format: Article
• Language: English
• Published: Springer 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/16997/1/Oral%20vaccine%20of%20Lactococcus%20lactis%20harbouring%20pandemic%20H1N1%202009%20haemagglutinin1%20and%20nisP%20anchor%20fusion%20protein%20elevates%20anti-HA1%20sIgA%20levels%20in%20mice.pdf; http://psasir.upm.edu.my/id/eprint/16997/; http://link.springer.com/article/10.1007%2Fs10529-016-2034-2
• Institution: Universiti Putra Malaysia

Objective: An oral lactococcal-based vaccine which haboured the haemagglutinin1 (HA1) antigen fused to nisP anchor protein for the purpose of surface displaying the HA1 antigen was developed against H1N1 virus. Results: Recombinant L. lactis strains expressed HA1-nisP fusion proteins when induced wi...