Chemical constituents and biological activities of Glycosmis chlorosperma var. Elmeri (Merr.) stone (Rutaceae)

• Main Authors: Abdullah, Rosmiati, Rahmani, Mawardi, Ali, Abdul Manaf, Ismail, H.B.M., Sukari, Mohd Aspollah, Lian, Gwendoline Ee Cheng
• Format: Article
• Language: English; English
• Published: Faculty of Science, University of Malaya 2006
• Online Access: http://psasir.upm.edu.my/id/eprint/18299/1/Chemical%20constituents%20and%20biological%20activities%20of%20Glycosmis%20chlorosperma%20var.pdf; http://psasir.upm.edu.my/id/eprint/18299/
• Institution: Universiti Putra Malaysia

Detailed investigation on the leaves and barks of Glycosmis chlorosperma has led to the isolation and identification of a chalcone, dihydroglychalcone (1) and three sulphones - dambullin (2), sakambullin (3) and methylgerambullin (4), along with the common triterpene, stigmasterol. Compounds (1) (2) and (3) showed cytotoxic activity towards CEM-SS T-lymphoblastic cell lines. However, only dambullin (2) showed activity against pathogenic bacteria and fungi. We wish to report the isolation and bioassay results of the crude extracts and pure compounds.