miR-137-mediated loss of KDM5B expression leads to suppression of the malignant phenotype of bladder cancer cells

• Main Authors: Kodiappan, Radha, Lai, Jiun Yee, Chan, Soon Choy, Rosli, Rozita, Nordin, Norshariza, Hussin, Huzlinda, Abd. Ghani, Fauzah, Yunus, Rosna, Abdul Razack, Azad Hassan, Ong, Teng Aik, Veerakumarasivam, Abhimanyu
• Format: Conference or Workshop Item
• Language: English
• Published: UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/20169/1/ABSTRACT%20CAC%202014_2%20medic%2021.pdf; http://psasir.upm.edu.my/id/eprint/20169/
• Institution: Universiti Putra Malaysia

The oncogenic role of KDM5B is implicated in the pathogenesis of many cancers including bladder cancer (BC). KDM5B is a histone demethylase enzyme that modifies the chromatin structure to specify cellular transcriptional states. Overexpression of KDM5B in cancer cells is correlated with an increased...