Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.

• Main Authors: Cheah, Pike See, Ramshaw, H. S., Thomas, P. Q., Toyo-oka, K., Xu, X., Martin, S., Coyle, P., Guthridge, M. A., Stomski, F., Van den Buuse, M., Wynshaw-Boris, A., Lopez, A. F., Schwarz, Q. P.
• Format: Article
• Language: English; English
• Published: Nature Publishing Group 2012
• Online Access: http://psasir.upm.edu.my/id/eprint/24411/1/Neurodevelopmental%20and%20neuropsychiatric%20behaviour%20defects%20arise%20from%2014.pdf; http://psasir.upm.edu.my/id/eprint/24411/; http://www.nature.com/mp/index.html
• Institution: Universiti Putra Malaysia

Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Here, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those s...