Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73.

• Main Authors: Wong, Su Wei, Tiong, Kai Hung, Kong, Kong, Yue, Yuen Chee, Chua, Choon Hooi, Lim, Jae Ying, Lee, Chai Yuin, Quah, Sean I., Fow, Cindy, Chung, Cyril, So, Irene, Tan, Boon Shing, Choo, Heng Lungh, Rosli, Rozita, Cheong, Soon Keng, Leong, Chee Onn
• Format: Article
• Language: English; English
• Published: Springer Verlag 2011
• Online Access: http://psasir.upm.edu.my/id/eprint/24421/1/Rapamycin%20synergizes%20cisplatin%20sensitivity%20in%20basal.pdf; http://psasir.upm.edu.my/id/eprint/24421/
• Institution: Universiti Putra Malaysia

Recent gene expression profiling studies have identified five breast cancer subtypes, of which the basal-like subtype is the most aggressive. Basal-like breast cancer poses serious clinical challenges as there are currently no targeted therapies available to treat it. Although there is increasing ev...