New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa.

• Main Authors: Matsuo, Hirotaka, Okamoto, Ryuichi, Zaima, Kazumasa, Hirasawa, Yusuke, Ismail, Intan Safinar, Lajis, Md. Nordin, Morita, Hiroshi
• Format: Article
• Language: English; English
• Published: Elsevier 2011
• Online Access: http://psasir.upm.edu.my/id/eprint/24848/1/New%20vasorelaxant%20indole%20alkaloids.pdf; http://psasir.upm.edu.my/id/eprint/24848/; http://www.elsevier.com/
• Institution: Universiti Putra Malaysia

Villocarines A–D (1–4), four new indole alkaloids have been isolated from the leaves of Uncaria villosa (Rubiaceae) and their structures were elucidated by 2D NMR methods and chemical correlations. Villocarine A (1) showed vasorelaxation activity against rat aortic ring and showed inhibition effect...