The In Vitro Bactericidal Activity of Normal and Activated Mouse Macrophages against Salmonella typhimurium C5sr
A comparison of the in vitro bactericidaL activity of normaL and activated macrophages indicated that killing of the viruLent strain of opsonized Salmonella typhimurium C5sr by normaL macrophages was enhanced by the presence of fresh serum in the cuLture medium. In contrast, there was no such requ...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
1990
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| Online Access: | http://psasir.upm.edu.my/id/eprint/2913/1/The_In_Vitro_Bactericidal_Activity_of_Normal_and_Activated.pdf http://psasir.upm.edu.my/id/eprint/2913/ |
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| Institution: | Universiti Putra Malaysia |
| Language: | English English |
| Summary: | A comparison of the in vitro bactericidaL activity of normaL and activated macrophages indicated that killing
of the viruLent strain of opsonized Salmonella typhimurium C5sr by normaL macrophages was enhanced
by the presence of fresh serum in the cuLture medium. In contrast, there was no such requirement for the
bactericidaL activity of activated macrophages. The enhanced killing ojfthe bacteria by activated macrophages
occurred both in the presence and absence of serum, and this was not accounted for by the existence of macrophagebound
immunogLobuLin. The factors in normaL rabbit serum which potentiated the killing of bacteria by
normaL macrophages were suspected to be components of the compLement system. Heat-stabLe jactors
(immunogLobuLins) in normaL rabbit serum were effective only if they were surface bound immunogLobuLins. |
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