Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function

• Main Authors: Hocker, Harrison J., Cho, Kwang Jin, Chen, Chung Ying K., Rambahal, Nandini, Sagineedu, Sreenivasa Rao, Shaari, Khozirah, Stanslas, Johnson, Hancock, John F., Gorfe, Alemayehu A.
• Format: Book Section
• Published: National Academy of Sciences 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29800/
• Institution: Universiti Putra Malaysia

Aberrant signaling by oncogenic mutant rat sarcoma (Ras)proteins occurs in ∼15% of all human tumors, yet direct inhibition of Ras by small molecules has remained elusive. Recently, several smallmolecule ligands have been discovered that directly bind Ras and inhibit its function by interfering with...