Neuroprotective effect from stem bark extracts of Knema laurina against H₂O₂- and Aβ(1-42)-induced cell death in human SH-SY5Y cells

• Main Authors: Ismail, Norsharina, Akhtar, Muhammad Nadeem, Ismail, Maznah, Zareen, Seema, Shah, Syed Adnan Ali, Lajis, Nordin, Tajuddin, Saiful Nizam
• Format: Article
• Published: Taylor & Francis 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/34639/; http://www.tandfonline.com/doi/full/10.1080/14786419.2014.985676
• Institution: Universiti Putra Malaysia

The stem bark extracts of Knema laurina inhibited the hydrogen peroxide (H2O2)- and aggregated amyloid β-peptide 1–42 length (Aβ1–42)-induced cell death in differentiated SH-SY5Y cells. Exposure of 250 μM H2O2 or 20 μM Aβ1–42 to the cells for 24 h reduced 50% of cell viability. Pretreatment of cells...