SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells

• Main Authors: Wong, Hui Chyn, Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Loke, Seng Cheong, Lajis, Nordin, Stanslas, Johnson
• Format: Article
• Published: Springer 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/35445/; http://link.springer.com/article/10.1007%2Fs10565-014-9282-5
• Institution: Universiti Putra Malaysia

Purpose 3,19-(3-Chloro-4-fluorobenzylidene)andrographolide (SRJ23), a new semisynthetic derivative of andrographolide (AGP), exhibited selectivity against prostate cancer cells in the US National Cancer Institute (NCI) in vitro anti-cancer screen. Herein, we report the in vitro growth inhibition an...