Bortezomib attenuates HIF-1- but not HIF-2-mediated transcriptional activation
Bortezomib is the first proteasomal inhibitor (PI) to be used therapeutically for treating relapse cases of multiple myeloma and mantle cell lymphoma. A proposed mechanism for its action is that it prevents the proteasomal degradation of proapoptotic proteins, leading to enhanced apoptosis. Although...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Spandidos Publications
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36675/1/Bortezomib%20attenuates%20HIF-1-%20but%20not%20HIF-2-mediated%20transcriptional%20activation.pdf http://psasir.upm.edu.my/id/eprint/36675/ https://www.spandidos-publications.com/10.3892/ol.2015.3545/abstract |
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| Institution: | Universiti Putra Malaysia |
| Language: | English |