Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats
About 24 healthy female Sprague-Dawley rats weighing between 300-350 g were used in this study over a 20 day period. They were allocated randomly into 4 groups of 6 animals each. After the creation of 2x2 cm open wound, group 1 was control treated with Gentamycin ointment. Groups 2-4 were treated wi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medwell Journals
2014
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/36808/1/Collagen.pdf http://psasir.upm.edu.my/id/eprint/36808/ http://medwelljournals.com/abstract/?doi=rjbsci.2014.57.61 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universiti Putra Malaysia |
| Language: | English |
| Summary: | About 24 healthy female Sprague-Dawley rats weighing between 300-350 g were used in this study over a 20 day period. They were allocated randomly into 4 groups of 6 animals each. After the creation of 2x2 cm open wound, group 1 was control treated with Gentamycin ointment. Groups 2-4 were treated with Therapeutic ultrasound massage, collagen-calcium alginate film and collagen-calcium alginate film with therapeutic ultrasound. On application, the collagen-calcium alginate film with therapeutic ultrasound was well accepted by the animals without any adverse reaction. Mean percentage of wound contraction were significantly better in group 4 (p<0.05). Faster epithelialization was also seen in the collagen-calcium alginate film with therapeutic ultrasound treated group as compared to the other groups. Collagen is a biocompatible protein that does not interfere with the body’s normal immunologic response and can be used in non-healing chronic wounds which require a trigger to stimulate the normal healing process. In extensive wounds when there is lack of autologous tissue, biomaterials like collagen-calcium alginate may be beneficial and can be used. |
|---|