Germinated brown rice alters Aβ(1-42) aggregation and modulates Alzheimer's disease-related genes in differentiated human SH-SY5Y cells

• Main Authors: Azmi, Nur Hanisah, Ismail, Maznah, Ismail, Norsharina, Imam, Mustapha Umar, Mohamed Alitheen, Noorjahan Banu, Abdullah, Maizaton Atmadini
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/37599/1/37599.pdf; http://psasir.upm.edu.my/id/eprint/37599/; http://www.hindawi.com/journals/ecam/2015/153684/abs/
• Institution: Universiti Putra Malaysia

The pathogenesis of Alzheimer’s disease involves complex etiological factors, of which the deposition of beta-amyloid (Aβ) protein and oxidative stress have been strongly implicated. We explored the effects of H2O2, which is a precursor for highly reactive hydroxyl radicals, on neurotoxicity and gen...