A statistical study on the development of metronidazole-chitosan-alginate nanocomposite formulation using the full factorial design

• Main Authors: Sabbagh, Hazem Abdul Kader, Hussein-Al-Ali, Samer Hasan, Hussein, Mohd Zobir, Abudayeh, Zead, Ayoub, Rami, Abudoleh, Suha Mujahed
• Format: Article
• Language: English
• Published: MDPI 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/38158/1/38158.pdf; http://psasir.upm.edu.my/id/eprint/38158/; https://www.mdpi.com/2073-4360/12/4/772
• Institution: Universiti Putra Malaysia

The goal of this study was to develop and statistically optimize the metronidazole (MET), chitosan (CS) and alginate (Alg) nanoparticles (NP) nanocomposites (MET-CS-AlgNPs) using a (21 × 31 × 21) × 3 = 36 full factorial design (FFD) to investigate the effect of chitosan and alginate polymer concentr...