Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia

• Main Authors: Mohd Tohit, Eusni Rahayu, Leong, Chooi Fun, Shuib, Salwati
• Format: Article
• Language: English
• Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2012
• Online Access: http://psasir.upm.edu.my/id/eprint/41205/1/Trisomy%20X%20and%20Myelodysplastic%20Syndrome%20%28MDS%29%20with%20eosinophilia.pdf; http://psasir.upm.edu.my/id/eprint/41205/; http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2012V08N2_CS01.pdf
• Institution: Universiti Putra Malaysia

We reported a young patient with myelodysplastic syndrome (MDS) with eosinophilia, in which her chromosomal analysis revealed the presence of trisomy X and a marker chromosome at chromosome 11. The technique used to detect the chromosomal abnormalities is a multicoloured –fluorescent in situ hybridization technique (M-FISH). Our observation suggested that these underlying chromosomal abnormalities were probably responsible for her development of MDS with eosinophilia. Myelodysplastic syndrome (MDS) is a condition whereby there is ineffective production of haematopoietic stem cells and poor quality of cells produced. The cause can either be a primary bone marrow problem, de novo or therapy related. Most MDS cases are secondary rather than primary. Many chromosomal abnormalities have been found in cases of myelodysplastic syndrome. We described a case of MDS with eosinophilia in association with presence of trisomy X and a marker chromosome in chromosome 11.