PIK3CA gene mutations in breast carcinoma in Malaysian patients

• Main Authors: Leong, Vincent Ching Shian, Jabal, Mohd Faizal, Leong, Pooi Pooi, Abdullah, Maizaton Atmadini, Alif Gul, Yunus Gul, Seow, Heng Fong
• Format: Article
• Language: English
• Published: Elsevier 2008
• Online Access: http://psasir.upm.edu.my/id/eprint/42238/1/PIK3CA%20gene%20mutations%20in%20breast%20carcinoma%20in%20Malaysian%20patients.pdf; http://psasir.upm.edu.my/id/eprint/42238/
• Institution: Universiti Putra Malaysia

Somatic mutations of phosphoinositide-3-kinase, catalytic, α; PIK3CA gene have been reported in several types of human cancers. The majority of the PIK3CA mutations map to the three “hot spots” — E542 K and E545 K in the helical (exon 9) and H1047R in the kinase (exon 20) domains of the p110α. These...