Ultrasonic emulsification of parenteral valproic acid-loaded nanoemulsion with response surface methodology and evaluation of its stability

• Main Authors: Tan, Suk Fei, Masoumi, Hamid Reza Fard, Karjiban, Roghayeh Abedi, Stanslas, Johnson, Kirby, Brian P., Basri, Mahiran, Basri, Hamidon
• Format: Article
• Language: English
• Published: Elsevier 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/43429/1/Ultrasonic%20emulsification%20of%20parenteral%20valproic%20acid-loaded%20nanoemulsion%20with%20response%20surface%20methodology%20and%20evaluation%20of%20its%20stability.pdf; http://psasir.upm.edu.my/id/eprint/43429/; http://www.sciencedirect.com/science/article/pii/S1350417715300377
• Institution: Universiti Putra Malaysia

Response surface methodology (RSM) was used to optimize the formulation of a nanoemulsion for central delivery following parenteral administration. A mixture of medium-chain triglyceride (MCT) and safflower seed oil (SSO) was determined as a sole phase from the emulsification properties. Similarly,...