An N-terminal extension to the hepatitis B virus core protein forms a poorly ordered trimeric spike in assembled virus-like particles

• Main Authors: McGonigle, Richard, Wei, Boon Yap, Swee, Tin Ong, Gatherer, Derek, Bakkera, Saskia E., Wen, Siang Tan, Bhella, David
• Format: Article
• Language: English
• Published: Elsevier 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/43732/1/An%20N-terminal%20extension%20to%20the%20hepatitis%20B%20virus%20core%20protein%20forms%20a%20poorly%20ordered%20.pdf; http://psasir.upm.edu.my/id/eprint/43732/; http://www.sciencedirect.com/science/article/pii/S1047847714002809
• Institution: Universiti Putra Malaysia

Virus-like particles composed of the core antigen of hepatitis B virus (HBcAg) have been shown to be an effective platform for the display of foreign epitopes in vaccine development. Heterologous sequences have been successfully inserted at both amino and carboxy termini as well as internally at the...