Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals

• Main Authors: Zakaria, Zainul Amiruddin, Abdul Ghani, Zuleen Delina Fasya, Raden Mohd Nor, Raden Nur Suraya, Gopalan, Hanan Kumar, Sulaiman, Mohd Roslan, Abdullah, Fatimah Corazon
• Format: Article
• Language: English
• Published: The Pharmaceutical Society of Japan 2006
• Online Access: http://psasir.upm.edu.my/id/eprint/48556/1/Antinociceptive%20and%20anti-inflammatory%20activities%20of%20Dicranopteris%20linearis%20leaves%20chloroform%20extract%20in%20experimental%20animals.pdf; http://psasir.upm.edu.my/id/eprint/48556/; https://www.jstage.jst.go.jp/article/yakushi/126/11/126_11_1197/_article
• Institution: Universiti Putra Malaysia

The present study was carried out to establish the antinociceptive and anti-inflammatory properties of Dicranopteris linearis leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, formalin and hot plate tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by evaporation under vacuo (40°C) to dryness, was dissolved in dimethyl sulfoxide to the doses of 20, 100 and 200 mg/kg and administered subcutaneously 30 min prior to subjection to the above mentioned assays. The extract, at all doses used, was found to exhibit significant (p<0.05) antinociceptive activity in a dose-dependent manner. However, the significant (p<0.05) anti-inflammatory activity observed occur in a dose-independent manner. As a conclusion, the chloroform extract of D. linearis possesses antinociceptive and anti-inflammatory activity and thus justify its traditional uses by the Malays to treat various ailments.