Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats

• Main Authors: Ebrahimi, Mahdi, Rajion, Mohamed Ali, Goh, Yong Meng, Farjam, Abdoreza Soleimani, Oskoueian, Ehsan, Jafari, Saeid
• Format: Article
• Language: English
• Published: Pontificia Universidad Católica de Valparaíso 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/52022/1/Diet%20high%20in%20%CE%B1-linolenic%20acid%20up-regulate%20PPAR-%CE%B1%20gene%20expression%20in%20the%20liver%20of%20goats.pdf; http://psasir.upm.edu.my/id/eprint/52022/; http://www.sciencedirect.com/science/article/pii/S0717345815000457
• Institution: Universiti Putra Malaysia

Background: There is little information on the effects of diets containing high α-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high α-linolenic acid or a control diet without added flaxseed oil (CON) for 100-d to evaluate the effects on liver lipid composition and the gene expression of peroxisome proliferator-activated receptors (PPAR-α) and stearoyl-CoA-desaturase (SCD) in the liver. Results: An increase in the levels of C18:3n-3 and C20:5n-3, C22:5n-3, C22:6n-3 was observed in the liver of FSO-treated goats. There was a significant (P < 0.05) up-regulation of PPAR-α gene expression and downregulation of SCD gene in the liver of goats fed the high α-linolenic acid diet. Conclusions: In conclusion, genes associated with the control of fatty acid (FA) conversion (SCD and PPAR) were affected by the α-linolenic acid supplementation in the goat diet. It is suggested that PPAR-α is the key messenger responsible for the translation of nutritional stimuli into changes in hepatic gene expression.