Newcastle disease virus degrades HIF-1a through proteasomal pathways independent of VHL and p53

• Main Authors: Abd Aziz, Noraini, Stanbridge, Eric John, Shafee, Norazizah
• Format: Article
• Language: English
• Published: The Microbiology Society 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/53381/1/Newcastle%20disease%20virus%20degrades%20HIF-1%CE%B1%20through%20proteasomal%20pathways%20independent%20of%20VHL%20and%20p53.pdf; http://psasir.upm.edu.my/id/eprint/53381/; https://www.semanticscholar.org/paper/Newcastle-disease-virus-degrades-HIF-1%CE%B1-through-pr-Abd-Aziz-Stanbridge/9be42407e2c13b3670e1034911854c22a90361d9
• Institution: Universiti Putra Malaysia

Newcastle disease virus (NDV) is a candidate agent for oncolytic virotherapy. Despite its potential, the exact mechanism of its oncolysis is still not known. Recently, we reported that NDV exhibited an increased oncolytic activity in hypoxic cancer cells. These types of cells negatively affect thera...