Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia

• Main Authors: Abdul Aziz, Zariah, Lee, Yvonne Y. L., Sidek, Norsima Nazifah, Awang Ngah, Bahari, Looi, Irene, Hanip, Md.Rafia, Basri, Hamidon
• Format: Article
• Language: English
• Published: Taylor & Francis 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/54369/1/Gender%20disparities%20and%20thrombolysis%20use%20among%20patient%20with%20first-ever%20ischemic%20stroke%20in%20Malaysia.pdf; http://psasir.upm.edu.my/id/eprint/54369/; https://www.tandfonline.com/doi/abs/10.1080/01616412.2016.1178948?journalCode=yner20
• Institution: Universiti Putra Malaysia

Objective: Gender as an independent predictor in stroke has been well documented. However, data on gender differences among first-ever ischemic stroke in developing country are limited. We aim to describe gender effects on clinical characteristics, thrombolysis treatment received, and outcomes of patients with first-ever ischemic stroke. Methods: Data were extracted from the prospective multiethnic stroke registry, National Neurology Registry (NNEUR). Descriptive analysis and logistic regression were performed. Results: A total of 4762 first-ever ischemic stroke patients admitted to 13 government hospitals from July 2009 to June 2015 were available for this study. Slightly over half were male (55.1%), and they were 1.7 years younger than female (mean age, 63.6 versus 61.9 years, p < 0.001). Gender–age-adjusted incidence was observed to be higher in females (66.7 per 100,000) compared to males (57.4 per 100,000). First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. Female experienced significantly poorer functional outcome and greater 30-day in-hospital mortality compared to male. In subgroup analysis, only 31 (0.65%) patients were treated with thrombolysis. Discussion: First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. There were distinct symptoms at hospital presentation between genders. All our patients discharged home regardless of genders. In summary, Malaysian female first-ever ischemic stroke was older, present with severe stroke, greater number of risk factors and poorer functional outcome and 30-day in-hospital mortality compared to male.