Danger lurking in the ‘‘unknowns’’: structure-to-function studies of hypothetical protein Bleg1_2437 from Bacillus lehensis G1 alkaliphile revealed an evolutionary divergent B3 metallo-beta-lactamase

• Main Authors: Tan, Soo Huei, Mohd Yahaya, Normi, Leow, Adam Thean Chor, Salleh, Abu Bakar, Abdul Murad, Abdul Munir, Mahadi, Nor Muhammad, Abdul Rahman, Mohd Basyaruddin
• Format: Article
• Language: English
• Published: Oxford University Press 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/61279/1/Danger%20lurking%20in%20the%20unknowns.pdf; http://psasir.upm.edu.my/id/eprint/61279/; https://academic.oup.com/jb/article/161/2/167/2725256
• Institution: Universiti Putra Malaysia

The effectiveness of β-lactam antibiotics as chemotherapeutic agents to treat bacterial infections is gradually threatened with the emergence of antibiotic resistance mechanism among pathogenic bacteria through the production metallo-β-lactamase (MBL). In this study, we discovered a novel hypothetic...